[CAS NO. 1801765-04-7] TNO155
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PRODUCTS SPECIFICATIONS [1801765-04-7]
Store
Catalog
SLK-S8987
Brand
Selleck
CAS
1801765-04-7
DESCRIPTION [1801765-04-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 421.95 |
| Molecular Formula | C18H24ClN7OS |
| SMILES | N[C@@H]1[C@@H](OCC12CCN(CC2)C3=NC(N)=C(N=C3)SC4=C(C(N)=NC=C4)Cl)C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3699 mL | 11.8497 mL | 23.6995 mL |
| 5 mM | 0.4740 mL | 2.3699 mL | 4.7399 mL |
| 10 mM | 0.2370 mL | 1.1850 mL | 2.3699 mL |
| 50 mM | 0.0474 mL | 0.2370 mL | 0.4740 mL |
Description
TNO155 is an inhibitor of with IC50 of 0.011 µM. TNO155 has potential antineoplastic activity.
Targets
| SHP-2 [1] (Cell-free assay) |
| 0.011 μM |
In vitro
TNO155 inhibits KYSE520 pERK and KYSE520 5-day cell proliferation with IC50 of 0.008 µM and of 0.100 µM, respectively. The off-target IC50 are 18 µM, 6.9 µM, 11 µM and > 30μM for Cav1.2, VMAT, SST3 and all others, respectively.
References
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