[CAS NO. 2381037-82-5] Atamparib (RBN-2397)

Name: Atamparib (RBN-2397)
Brand: Arctom Scientific
SKU: SLK-S8993

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PRODUCTS SPECIFICATIONS [2381037-82-5]

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Catalog

SLK-S8993

Brand

Selleck

CAS

2381037-82-5

DESCRIPTION [2381037-82-5]

Overview

MDL	-
Molecular Weight	523.43
Molecular Formula	C20H23F6N7O3
SMILES	O=C1C(C(F)(F)F)=C(N[C@@H](C)COCCC(N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)=O)C=NN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9105 mL	9.5524 mL	19.1048 mL
5 mM	0.3821 mL	1.9105 mL	3.8210 mL
10 mM	0.1910 mL	0.9552 mL	1.9105 mL
50 mM	0.0382 mL	0.1910 mL	0.3821 mL

Description

Atamparib (RBN-2397) is a potent, selective and orally active NAD+ competitive inhibitor with IC50 of <3 nM and Kd of <0.001 μM. RBN-2397 has the potential for the research of tumor treatment.

Targets

PARP7 ^[1] (Cell-free assay)	PARP7 ^[1] (Cell-free assay)
<0.001 μM(Kd)	<3 nM

In vitro

RBN-2397 restores cytosolic nucleic acid sensing and blocks cell proliferation in a human lung cancer cell line.

References

[1] Melissa Vasbinder. RBN-2397: A First-in-Class PARP7 Inhibitor Targeting a Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways.