[CAS NO. 163239-22-3] 680C91
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PRODUCTS SPECIFICATIONS [163239-22-3]
Store
Catalog
SLK-S8997
Brand
Selleck
CAS
163239-22-3
DESCRIPTION [163239-22-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 238.26 |
| Molecular Formula | C15H11FN2 |
| SMILES | C(=C/C=1C=CC=NC1)\C=2C=3C(NC2)=CC(F)=CC3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1971 mL | 20.9855 mL | 41.9710 mL |
| 5 mM | 0.8394 mL | 4.1971 mL | 8.3942 mL |
| 10 mM | 0.4197 mL | 2.0985 mL | 4.1971 mL |
| 50 mM | 0.0839 mL | 0.4197 mL | 0.8394 mL |
Description
680C91 is a potent and selective inhibitor of with Ki of 51 nM.
Targets
| TDO [1] (Cell-free assay) |
| 51 nM(Ki) |
In vitro
68OC91 is a potent (Ki = 51 nM) and selective TDO inhibitor with no inhibitory activity against indoleamine 2,3-dioxygenase (EC 1.13.11.17), monoamine oxidase A and B, 5-HT uptake and 5-HT and receptors at a concentration of 10 μM. 68OC91 has no effect on the binding of tryptophan to serum albumin in plasma and inhibited TDO competitively with respect to its substrate tryptophan. 68OC91 inhibits the catabolism of tryptophan by rat liver cells and rat liver perfused in .
References
Synonyms
1H-Indole, 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-
1H-Indole, 6-fluoro-3-[2-(3-pyridinyl)ethenyl]-, (E)-
6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole
680C91
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