[CAS NO. 478-61-5] Berbamine

Name: Berbamine
Brand: Arctom Scientific
SKU: SLK-S9141

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PRODUCTS SPECIFICATIONS [478-61-5]

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Catalog

SLK-S9141

Brand

Selleck

CAS

478-61-5

DESCRIPTION [478-61-5]

Overview

MDL	-
Molecular Weight	608.72
Molecular Formula	C37H40N2O6
SMILES	O(C)C1=C2C3=C(C=C1OC)CCN(C)[C@@]3(CC=4C=C(OC=5C=CC(C[C@]6(C7=CC(O2)=C(OC)C=C7CCN6C)[H])=CC5)C(O)=CC4)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.6428 mL	8.2140 mL	16.4279 mL
5 mM	0.3286 mL	1.6428 mL	3.2856 mL
10 mM	0.1643 mL	0.8214 mL	1.6428 mL
50 mM	0.0329 mL	0.1643 mL	0.3286 mL

Description

Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of fusion gene with potent anti-leukemia activity and also an inhibitor of . Berbamine (BA) induces in human myeloma cells and inhibits the growth of cancer cells by targeting .

Targets

Bcr-Abl ^[1]

NF-κB ^[2]

CaMKII ^[3]

References

[1] Rongzhen Xu, et al. Leuk Res . 2006 Jan;30(1):17-23.
[2] Yun Liang, et al. Acta Pharmacol Sin . 2009 Dec;30(12):1659-65.
[3] Zhipeng Meng, et al. Mol Cancer Ther . 2013 Oct;12(10):2067-77.

Synonyms

16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, (4aS,16aR)-

Berbamine

Berbaman-12-ol, 6,6′,7-trimethoxy-2,2′-dimethyl-

(4aS,16aR)-3,4,4a,5,16a,17,18,19-Octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol

Berbenine

16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, [4aS-(4aR*,16aS*)]-

d-Berbamine

(+)-Berbamine

NSC 121842