[CAS NO. 114482-86-9] Oroxin B

Name: Oroxin B
Brand: Arctom Scientific
SKU: SLK-S9190

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PRODUCTS SPECIFICATIONS [114482-86-9]

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Catalog

SLK-S9190

Brand

Selleck

CAS

114482-86-9

DESCRIPTION [114482-86-9]

Overview

MDL	-
Molecular Weight	594.52
Molecular Formula	C27H30O15
SMILES	OC1=C2C(OC(=CC2=O)C3=CC=CC=C3)=CC(O[C@@H]4O[C@H](CO[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)=C1O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.6820 mL	8.4101 mL	16.8203 mL
5 mM	0.3364 mL	1.6820 mL	3.3641 mL
10 mM	0.1682 mL	0.8410 mL	1.6820 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL

Description

Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce , which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer. expression levels are downregulated, while is upregulated after Oroxin B treatment.

Targets

PTEN ^[1]

COX-2 ^[1]

PI3K ^[1]

Akt ^[1]

References

[1] Nan-Nan Li, et al. Pharmacogn Mag . Apr-Jun 2018;14(54):207-213.

Synonyms

4H-1-Benzopyran-4-one, 7-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-5,6-dihydroxy-2-phenyl-

7-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Baicalein 7-O-β-gentiobioside

Baicalein 7-O-diglucoside

Oroxin B