[CAS NO. 483-90-9] Toddalolactone
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PRODUCTS SPECIFICATIONS [483-90-9]
Store
Catalog
SLK-S9194
Brand
Selleck
CAS
483-90-9
DESCRIPTION [483-90-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 308.33 |
| Molecular Formula | C16H20O6 |
| SMILES | C([C@H](C(C)(C)O)O)C=1C(OC)=C2C(=CC1OC)OC(=O)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Toddalolactone, a natural coumarin, inhibits the activity of recombinant human in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.
Targets
| PAI-1 [1] |
| 37.31 μM |
In vitro
Toddalolactone inhibits the binding between PAI-1 and uPA, and therefore prevented the formation of the PAI-1/uPA complex.
In vivo
Intraperitoneal injection of toddalolactone in mice significantly prolonged tail bleeding and reduced arterial thrombus weight in a FeCl3-induced thrombosis model. Moreover, the hydroxyproline level in the plasma and the degree of liver fibrosis in mice were decreased after intraperitoneal injection of toddalolactone in CCl4-induced mouse liver fibrosis model.
Synonyms
2H-1-Benzopyran-2-one, 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-
Coumarin, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy-
Toddalolactone
2H-1-Benzopyran-2-one, 6-(2,3-dihydroxy-3-methylbutyl)-5,7-dimethoxy-, (R)-
6-[(2R)-2,3-Dihydroxy-3-methylbutyl]-5,7-dimethoxy-2H-1-benzopyran-2-one
(+)-Toddalolactone
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