[CAS NO. 20501-56-8] Talatisamine
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PRODUCTS SPECIFICATIONS [20501-56-8]
Store
Catalog
SLK-S9223
Brand
Selleck
CAS
20501-56-8
DESCRIPTION [20501-56-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 421.57 |
| Molecular Formula | C24H39NO5 |
| SMILES | O(C)[C@@H]1[C@]23[C@H]4[C@](COC)(CN(CC)[C@@]2([C@H](C4)[C@]5(O)[C@@]6([C@]3(C[C@@H]([C@@H]6O)[C@@H](OC)C5)[H])[H])[H])CC1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified blocker with hypotensive and antiarrhythmic activities.
Targets
| IK channel [1] |
| 146 μM |
In vitro
Talatisamine is a specific blocker for channel. External application of talatisamine reversibly inhibited the delayed rectifier K+ current (IK) with an IC50 value of 146.0±5.8 μM in a voltage-dependent manner, but exhibited very slight blocking effect on the voltage-gated Na+ and Ca2+ currents even at the high concentration of 1-3 mM in rat hippocampal neurons. Talatisamine had no allosteric action on IK channel and was a pure blocker binding to the external pore entry of the channel.
Synonyms
Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1α,14α,16β)-
Talatisamine
11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-8,14-diol deriv.
(1α,14α,16β)-20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol
Talatizamine
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