[CAS NO. 13476-25-0] Linderane

Name: Linderane
Brand: Arctom Scientific
SKU: SLK-S9229

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PRODUCTS SPECIFICATIONS [13476-25-0]

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Catalog

SLK-S9229

Brand

Selleck

CAS

13476-25-0

DESCRIPTION [13476-25-0]

Overview

MDL	-
Molecular Weight	260.29
Molecular Formula	C15H16O4
SMILES	O=C1C23[C@H](O2)[C@@](O1)(C4=C(OC=C4C)C/C(/C)=C\CC3)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Linderane, isolated from Lindera strychnifolia vill., is an indirect activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.

Targets

PDE3 ^[1]

In vitro

Linderane inhibits gluconeogenesis by activating hepatic PDE3 in rat primary hepatocytes. It reduces phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, and decreases intracellular cAMP concentration and CREB phosphorylation in rat primary hepatocytes under both basal and forskolin-stimulated conditions. Linderane also increases total PDE and PDE3 activity but not PDE4 activity in rat primary hepatocytes. Linderane indirectly activated PDE3 through extracellular regulated protein kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) activation.

In vivo

Linderane improved glucose and lipid metabolism after chronic oral administration in ob/ob mice.

References

[1] Xie W, et al. Front Pharmacol. 2018, 9:476.

Synonyms

2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one, 3,6,10,10a-tetrahydro-5,9-dimethyl-, (1aS,4E,10S,10aS)-

4βH-Germacra-1(10),7,11-trien-15-oic acid, 4,5β:8,12-diepoxy-6α-hydroxy-, γ-lactone, (E)-

2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one, 3,6,10,10a-tetrahydro-5,9-dimethyl-, [1aS-(1aR*,4E,10R*,10aR*)]-

Linderane

(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one