[CAS NO. 1422365-93-2] IM156
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PRODUCTS SPECIFICATIONS [1422365-93-2]
Store
Catalog
SLK-S9604
Brand
Selleck
CAS
1422365-93-2
DESCRIPTION [1422365-93-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 315.29 |
| Molecular Formula | C13H16F3N5O |
| SMILES | N=C(N1CCCC1)NC(NC2=CC=C(OC(F)(F)F)C=C2)=N |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1717 mL | 15.8584 mL | 31.7168 mL |
| 5 mM | 0.6343 mL | 3.1717 mL | 6.3434 mL |
| 10 mM | 0.3172 mL | 1.5858 mL | 3.1717 mL |
| 50 mM | 0.0634 mL | 0.3172 mL | 0.6343 mL |
Description
IM156 (HL156A), a metformin derivative, is a potent activator of that increases AMPK phosphorylation. IM156 blocks through the inhibition of and increases . IM156 ameliorates various types of fibrosis and inhibits tumors.
In vitro
IM156 (HL156A) treatment of RPMCs inhibits HG-induced myofibroblast transdifferentiation and markers of epithelial-mesenchymal transition (EMT). Moreover, IM156 (HL156A) ameliorates HG-induced transforming growth factor-β1, Smad3, Snail, and fibronectin expression in the RPMCs via AMPK upregulation. IM156 treatment decreases complex I-dependent NADH oxidation in a significant, dose-dependent manner.
References
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