[CAS NO. 1032229-33-6] A939572
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [1032229-33-6]
Store
Catalog
SLK-S9607
Brand
Selleck
CAS
1032229-33-6
DESCRIPTION [1032229-33-6]
Overview
| MDL | MFCD10698997 |
|---|---|
| Molecular Weight | 387.86 |
| Molecular Formula | C20H22ClN3O3 |
| SMILES | O=C(N1CCC(OC2=CC=CC=C2Cl)CC1)NC3=CC=CC(C(NC)=O)=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5782 mL | 12.8912 mL | 25.7825 mL |
| 5 mM | 0.5156 mL | 2.5782 mL | 5.1565 mL |
| 10 mM | 0.2578 mL | 1.2891 mL | 2.5782 mL |
| 50 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL |
Description
A939572 is a potent and orally bioavailable inhibitor with IC50 of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.
In vitro
A939572 demonstrates a significant dose-dependent decrease in proliferation in Caki1, A498, Caki2, and ACHN at day 5. In congruity with previous experimentation examining SCD1 lentiviral knockdown models, A939572 induces apoptosis confirmed by PARP cleavage via western blot analysis in all four cell lines. Treatment of ccRCC cells with A939572 induces Endoplasmic Reticulum Stress.
References
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.