[CAS NO. 2239273-34-6] Etrumadenant (AB928)

Name: Etrumadenant (AB928)
Brand: Arctom Scientific
SKU: SLK-S9608

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PRODUCTS SPECIFICATIONS [2239273-34-6]

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Catalog

SLK-S9608

Brand

Selleck

CAS

2239273-34-6

DESCRIPTION [2239273-34-6]

Overview

MDL	-
Molecular Weight	426.47
Molecular Formula	C23H22N8O
SMILES	N#CC1=CC=CC(C2=NC(N)=NC(C3=CN(CC4=NC(C(C)(O)C)=CC=C4)N=N3)=C2)=C1C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3448 mL	11.7242 mL	23.4483 mL
5 mM	0.4690 mL	2.3448 mL	4.6897 mL
10 mM	0.2345 mL	1.1724 mL	2.3448 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL

Description

Etrumadenant (AB928, A2aR/A2bR antagonist-1) is a novel dual antagonist with Kd of 1.4 nM and 2 nM for A2aR and A2bR, respectively.

Targets

A2AR ^[1] (Cell-free assay)	A2bR ^[1] (Cell-free assay)
1.4 nM(Kd)	2 nM(Kd)

In vitro

Consistent with the ability of adenosine to suppress immune function, AB928 inhibits the ability of adenosine to suppress CD4 or CD8 T cell activation.

References

[1] Lisa Seitz, et al. Invest New Drugs. 2019 Aug;37(4):711-721.
[2] Walters MJ, et al. Cancer Res 2018;78(13 Suppl):Abstract nr 5556.