[CAS NO. 57818-44-7] ABTL-0812
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [57818-44-7]
Store
Catalog
SLK-S9611
Brand
Selleck
CAS
57818-44-7
DESCRIPTION [57818-44-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 296.44 |
| Molecular Formula | C18H32O3 |
| SMILES | C(CCC(C(O)=O)O)CCC/C=C\C/C=C\CCCCC |
For research use only.
Storage
2 years -20°C liquid
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits axis by inducing the overexpression of TRIB3 and activating in lung squamous carcinoma cell lines. ABTL0812 also induces activation and accumulation.
In vitro
ABTL0812 inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. Furthermore, treatment with ABTL0812 also induces AMPK activation and ROS accumulation. Moreover, combination of ABTL0812 with chemotherapy markedly increases the therapeutic effect of chemotherapy without increasing toxicity. Combination of ABTL0812 and chemotherapy induces nonapoptotic cell death mediated by TRIB3 activation and autophagy induction.
Synonyms
9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-
9,12-Octadecadienoic acid, 2-hydroxy-, (Z,Z)-
(9Z,12Z)-2-Hydroxy-9,12-octadecadienoic acid
α-Hydroxylinoleic acid
2-Hydroxylinoleic acid
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.