[CAS NO. 1359993-59-1] Telratolimod
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PRODUCTS SPECIFICATIONS [1359993-59-1]
Store
Catalog
SLK-S9623
Brand
Selleck
CAS
1359993-59-1
DESCRIPTION [1359993-59-1]
Overview
| MDL | MFCD31692360 |
|---|---|
| Molecular Weight | 593.89 |
| Molecular Formula | C36H59N5O2 |
| SMILES | CCCCCCCCCCCCCCCCCC(NCCCCON1C(CCCC)=NC2=C1C3=CC=CC=C3N=C2N)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6838 mL | 8.4191 mL | 16.8381 mL |
| 5 mM | 0.3368 mL | 1.6838 mL | 3.3676 mL |
| 10 mM | 0.1684 mL | 0.8419 mL | 1.6838 mL |
| 50 mM | - | - | - |
Description
Telratolimod (3M-052, MEDI9197) is an agonist of and with antitumor activity.
In vitro
3M-052 induces both TNFα and IFNα in human PBMCs in a manner indicative of a dual TLR7/TLR8 agonist. 3M-052 stimulates the production of IL8 in HEK293 cells stably expressing either human TLR7 or TLR8. In contrast, no IL8 is stimulated in empty vector control cells. The TLR8 agonist activity of 3M-052 may be of particular value in the immunization of neonates and infants whose monocytes and antigen presenting cells have a diminished capacity to generate TH1 polarizing signals to TNFα and IFNα.
References
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