[CAS NO. ] DRB18

Name: DRB18
Brand: Arctom Scientific
SKU: SLK-S9636

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PRODUCTS SPECIFICATIONS

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Catalog

SLK-S9636

Brand

Selleck

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	382.88
Molecular Formula	C22H23ClN2O2
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6118 mL	13.0589 mL	26.1178 mL
5 mM	0.5224 mL	2.6118 mL	5.2236 mL
10 mM	0.2612 mL	1.3059 mL	2.6118 mL
50 mM	0.0522 mL	0.2612 mL	0.5224 mL

Description

DRB18 is a inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.

Targets

GLUT ^[1]

In vitro

DRB18 inhibits growth and proliferation in about 90% of the 60 different cancer cell lines in 9 major cancer types. DRB18 treatment leads to significant changes in glucose-based metabolism in A549 lung cancer cells, including cell death via ER/oxidative stress and necrosis.

References

[1] Pratik Shriwas, et al. Cancer Res 2020;80(16 Suppl):Abstract nr 4191.
[2] Shriwas P, et al. Cancer Metab. 2021 Mar 26;9(1):14.