[CAS NO. 2056261-41-5] BRD0705
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PRODUCTS SPECIFICATIONS [2056261-41-5]
Store
Catalog
SLK-S9638
Brand
Selleck
CAS
2056261-41-5
DESCRIPTION [2056261-41-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 321.42 |
| Molecular Formula | C20H23N3O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1112 mL | 15.5560 mL | 31.1119 mL |
| 5 mM | 0.6222 mL | 3.1112 mL | 6.2224 mL |
| 10 mM | 0.3111 mL | 1.5556 mL | 3.1112 mL |
| 50 mM | 0.0622 mL | 0.3111 mL | 0.6222 mL |
Description
BRD0705 is a potent, paralog selective and orally active inhibitor of with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).
Targets
In vitro
BRD0705 inhibits kinase function and does not stabilize β-catenin, mitigating potential neoplastic concerns. BRD0705 induces myeloid differentiation and impairs colony formation in AML cells while no effect is observed on normal hematopoietic cells.
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