[CAS NO. 2081072-29-7] NEO2734
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PRODUCTS SPECIFICATIONS [2081072-29-7]
Store
Catalog
SLK-S9648
Brand
Selleck
CAS
2081072-29-7
DESCRIPTION [2081072-29-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 435.44 |
| Molecular Formula | C22H24F3N3O3 |
| SMILES | O=C1C(C)=CC(C2=CC=C3N=C(C4CCOCC4)N(CCOC(F)(F)F)C3=C2)=CN1C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2965 mL | 11.4826 mL | 22.9653 mL |
| 5 mM | 0.4593 mL | 2.2965 mL | 4.5931 mL |
| 10 mM | 0.2297 mL | 1.1483 mL | 2.2965 mL |
| 50 mM | 0.0459 mL | 0.2297 mL | 0.4593 mL |
Description
NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of and with IC50 of both <30 nM.
In vitro
Treatment of NMC cells with the novel dual p300/CBP and BET bromodomain–selective inhibitor, NEO2734, potently inhibits growth and induces differentiation of NMC cells in vitro; findings that correspond with potentiated transcriptional effects from combined BET and p300 bromodomain inhibition.
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