[CAS NO. 2682114-54-9] SP-96
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PRODUCTS SPECIFICATIONS [2682114-54-9]
Store
Catalog
SLK-S9658
Brand
Selleck
CAS
2682114-54-9
DESCRIPTION [2682114-54-9]
Overview
| MDL | MFCD32858307 |
|---|---|
| Molecular Weight | 453.47 |
| Molecular Formula | C25H20FN7O |
| SMILES | FC1=CC(NC(NC2=CC(NC3=C(C=CC(C4=CN(C)N=C4)=C5)C5=NC=N3)=CC=C2)=O)=CC=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2052 mL | 11.0261 mL | 22.0522 mL |
| 5 mM | 0.4410 mL | 2.2052 mL | 4.4104 mL |
| 10 mM | 0.2205 mL | 1.1026 mL | 2.2052 mL |
| 50 mM | 0.0441 mL | 0.2205 mL | 0.4410 mL |
Description
SP-96 is a potent, selective and non-ATP-competitive inhibitor of with IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).
Targets
| Aurora B [1] (Cell-free assay) |
| 0.316 nM |
In vitro
SP-96 shows sub-nanomolar potency in Aurora B enzymatic assays (IC50 = 0.316 ± 0.031 nM). SP-96 shows >2000 fold selectivity against FLT3 and KIT which is important for normal hematopoiesis. Enzyme kinetics of SP-96 shows non-ATP competitive inhibition which makes it a first-in-class inhibitor. SP-96 shows selective growth inhibition in NCI60 screening, including inhibition of MDA-MD-468, a Triple Negative Breast Cancer cell line.
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