[CAS NO. 608512-97-6] PKR-IN-C16
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PRODUCTS SPECIFICATIONS [608512-97-6]
Store
Catalog
SLK-S9668
Brand
Selleck
CAS
608512-97-6
DESCRIPTION [608512-97-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 268.29 |
| Molecular Formula | C13H8N4OS |
| SMILES | C(=C1C=2C3=C(C=CC2NC1=O)N=CS3)C4=CN=CN4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7273 mL | 18.6366 mL | 37.2731 mL |
| 5 mM | 0.7455 mL | 3.7273 mL | 7.4546 mL |
| 10 mM | 0.3727 mL | 1.8637 mL | 3.7273 mL |
| 50 mM | - | - | - |
Description
PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of . PKR-IN-C16 prevents and production in an acute excitotoxic rat model with a neuroinflammatory component.
In vitro
PKR-IN-C16 suppresses proliferation of HCC cells in a dose-dependent manner in vitro. Transcript levels of vascular endothelial growth factor-A and factor-B, platelet-derived growth factor-A and factor-B, fibroblast growth factor-2, epidermal growth factor, and hepatocyte growth factor, which are angiogenesis-related growth factors, are significantly decreased by PKR-IN-C16 in vitro. PKR-IN-C16 blockes tumor cell growth and angiogenesis via a decrease in mRNA levels of several growth factors.
References
Synonyms
7H-Pyrrolo[2,3-g]benzothiazol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-
7H-Pyrrolo[2,3-g]benzothiazol-7-one, 6,8-dihydro-8-(1H-imidazol-4-ylmethylene)-
6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
GW 506033X
6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Imidazolo-oxindole PKR inhibitor C16
PKR inhibitor
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