[CAS NO. 495399-09-2] Saroglitazar

Name: Saroglitazar
Brand: Arctom Scientific
SKU: SLK-S9674

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PRODUCTS SPECIFICATIONS [495399-09-2]

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Catalog

SLK-S9674

Brand

Selleck

CAS

495399-09-2

DESCRIPTION [495399-09-2]

Overview

MDL	-
Molecular Weight	439.57
Molecular Formula	C25H29NO4S
SMILES	C(COC1=CC=C(C[C@H](OCC)C(O)=O)C=C1)N2C(=CC=C2C)C3=CC=C(SC)C=C3

For research use only.

Storage

2 years 4°C liquid
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Saroglitazar (Lipaglyn, ZYH1) is an agonist of with EC50 of 0.65 pM and 3 nM for hPPARα and hPPARγ in HepG2 cells, respectively.

Targets

hPPARα ^[1] (Cell-free assay)	hPPARγ ^[1] (Cell-free assay)
0.65 pM(EC50)	3 nM(EC50)

In vitro

Saroglitazar is a novel nonthiazolidinediones (TZD) and nonfibric acid derivative designed to act as dual regulator of lipids and glucose metabolism by activating peroxisome proliferator-activated receptors (PPAR). The EC50 values of Saroglitazar assessed in HepG2 cells using PPAR transactivation assay for hPPARa and hPPARc are 0.65 pmol/L and 3 nmol/L, respectively.

References

[1] Mukul R Jain, et al. Pharmacol Res Perspect. 2015 Jun;3(3):e00136.

Synonyms

Benzenepropanoic acid, α-ethoxy-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]-, (αS)-

(αS)-α-Ethoxy-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoic acid

Saroglitazar

Lipaglyn

(s)-2-Ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoic acid