[CAS NO. 129425-81-6] MSA-2
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PRODUCTS SPECIFICATIONS [129425-81-6]
Store
Catalog
SLK-S9681
Brand
Selleck
CAS
129425-81-6
DESCRIPTION [129425-81-6]
Overview
| MDL | MFCD32640674 |
|---|---|
| Molecular Weight | 294.32 |
| Molecular Formula | C14H14O5S |
| SMILES | O=C(O)CCC(C1=CC2=CC(OC)=C(OC)C=C2S1)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3977 mL | 16.9883 mL | 33.9766 mL |
| 5 mM | 0.6795 mL | 3.3977 mL | 6.7953 mL |
| 10 mM | 0.3398 mL | 1.6988 mL | 3.3977 mL |
| 50 mM | 0.0680 mL | 0.3398 mL | 0.6795 mL |
Description
MSA-2 is an orally available non-nucleotide human agonist with antitumor activity.
Targets
| STING [1] |
In vitro
MSA-2 in solution exists as monomers and noncovalent dimers in an equilibrium that strongly favors monomers; MSA-2 monomers cannot bind STING, whereas the noncovalent MSA-2 dimers bind STING with nanomolar affinity. MSA-2 exhibits substantially higher cellular potency in an acidified tumor microenvironment than normal tissue, owing to increased cellular entry and retention combined with the inherently steep MSA-2 concentration dependence of STING occupancy.
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