[CAS NO. 168682-53-9] Ezatiostat
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PRODUCTS SPECIFICATIONS [168682-53-9]
Store
Catalog
SLK-S9698
Brand
Selleck
CAS
168682-53-9
DESCRIPTION [168682-53-9]
Overview
| MDL | MFCD27982957 |
|---|---|
| Molecular Weight | 643.67 |
| Molecular Formula | C29H36F3N3O8S |
| SMILES | O=C(N[C@@H](C(OCC)=O)C1=CC=CC=C1)[C@@H](NC(CC[C@H](N)C(OCC)=O)=O)CSCC2=CC=CC=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5536 mL | 7.7680 mL | 15.5359 mL |
| 5 mM | 0.3107 mL | 1.5536 mL | 3.1072 mL |
| 10 mM | 0.1554 mL | 0.7768 mL | 1.5536 mL |
| 50 mM | 0.0311 mL | 0.1554 mL | 0.3107 mL |
Description
Ezatiostat (TER199, TLK199, Telintra), a tripeptide analog of glutathione, is a peptidomimetic inhibitor of . Ezatiostat activates and and induces .
In vitro
Selection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allows the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells.
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