[CAS NO. 1050477-31-0] Finerenone
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PRODUCTS SPECIFICATIONS [1050477-31-0]
Store
Catalog
SLK-S9702
Brand
Selleck
CAS
1050477-31-0
DESCRIPTION [1050477-31-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 378.42 |
| Molecular Formula | C21H22N4O3 |
| SMILES | O(CC)C1=C2[C@@H](C(C(N)=O)=C(C)NC2=C(C)C=N1)C3=C(OC)C=C(C#N)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6426 mL | 13.2128 mL | 26.4257 mL |
| 5 mM | 0.5285 mL | 2.6426 mL | 5.2851 mL |
| 10 mM | 0.2643 mL | 1.3213 mL | 2.6426 mL |
| 50 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL |
Description
Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
Targets
| MR [1] (Cell-free assay) |
| 18 nM |
In vitro
In vitro, Finerenone dose-dependently reduces aldosterone-induced smooth muscle cell (SMC) proliferation and prevents aldosteroneinduced endothelial cell (EC) apoptosis. Finerenone significantly reduces apoptosis of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels.
References
Synonyms
1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-, (4S)-
(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide
BAY 94-8862
Finerenone
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