[CAS NO. 1800487-55-1] OT-82
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PRODUCTS SPECIFICATIONS [1800487-55-1]
Store
Catalog
SLK-S9706
Brand
Selleck
CAS
1800487-55-1
DESCRIPTION [1800487-55-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 424.47 |
| Molecular Formula | C26H21FN4O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3559 mL | 11.7794 mL | 23.5588 mL |
| 5 mM | 0.4712 mL | 2.3559 mL | 4.7118 mL |
| 10 mM | 0.2356 mL | 1.1779 mL | 2.3559 mL |
| 50 mM | 0.0471 mL | 0.2356 mL | 0.4712 mL |
Description
OT-82 is a novel inhibitor with average IC50s of 13.03 nM in non-HP cancer cells and 2.89 nM in HP cancer cells, respectively.
Targets
| NAMPT [1] (in hematopoietic cells) |
| 2.89 nM |
In vitro
OT-82 is an effective nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, thus inhibits the salvage pathway of NAD synthesis to kill the neoplastic cells of hematopoietic. The average IC50 is 13.03 nM in non-HP cancer cells and 2.89 nM in HP cancer cells.[1]
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