CH7233163
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PRODUCTS SPECIFICATIONS
Store
Catalog
SLK-S9711
Brand
Selleck
CAS
-
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 669.72 |
| Molecular Formula | C31H34F3N9O3S |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4932 mL | 7.4658 mL | 14.9316 mL |
| 5 mM | 0.2986 mL | 1.4932 mL | 2.9863 mL |
| 10 mM | 0.1493 mL | 0.7466 mL | 1.4932 mL |
| 50 mM | 0.0299 mL | 0.1493 mL | 0.2986 mL |
Description
CH7233163 is a non-covalent ATP competitive inhibitor of with antitumor activities against tumor with EGFR-Del19/T790M/C797S.
Targets
| EGFR [1] |
In vitro
CH7233163 shows potent antitumor activities against tumor with EGFR-Del19/T790M/C797S in vitro. CH7233163 potently inhibits the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nmol/L. CH7233163 potently and dose-dependently blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 can inhibit Del19/T790M/C797S signaling.
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