[CAS NO. 1035688-66-4] ASLAN003

Name: ASLAN003
Brand: Arctom Scientific
SKU: SLK-S9721

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1035688-66-4]

Store

Catalog

SLK-S9721

Brand

Selleck

CAS

1035688-66-4

DESCRIPTION [1035688-66-4]

Overview

MDL	-
Molecular Weight	356.32
Molecular Formula	C19H14F2N2O3
SMILES	O=C(O)C1=C(NC2=C(F)C=C(C3=CC=CC(OC)=C3)C=C2F)N=CC=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8065 mL	14.0323 mL	28.0647 mL
5 mM	0.5613 mL	2.8065 mL	5.6129 mL
10 mM	0.2806 mL	1.4032 mL	2.8065 mL
50 mM	0.0561 mL	0.2806 mL	0.5613 mL

Targets

AP-1 ^[1]	AP-1 ^[1]	human DHODH ^[1] (Cell-free assay)
		35 nM

In vitro

ASLAN003 is a highly potent dihydroorotate dehydrogenase inhibitor that induces differentiation, as well as reducing cell proliferation and viability, of AML cell lines and primary AML blasts including chemoresistant cells. Apoptotic pathways are triggered by ASLAN003, and this drug also significantly inhibits protein synthesis and activates AP-1 transcription, contributing to its capacity to promote differentiation.

References

[1] Jianbiao Zhou, et al. Haematologica. 2019 Nov 7;105(9):2286-2297.