[CAS NO. 2100284-59-9] AZ3451
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PRODUCTS SPECIFICATIONS [2100284-59-9]
Store
Catalog
SLK-S9744
Brand
Selleck
CAS
2100284-59-9
DESCRIPTION [2100284-59-9]
Overview
| MDL | MFCD31692400 |
|---|---|
| Molecular Weight | 571.46 |
| Molecular Formula | C30H27BrN4O3 |
| SMILES | O=C(C1=CC=C2C(N=C(C3=C(Br)C=C(OCO4)C4=C3)N2[C@H](C5CCCCC5)C)=C1)NC6=CC=C(C#N)C=C6 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7499 mL | 8.7495 mL | 17.4990 mL |
| 5 mM | 0.3500 mL | 1.7499 mL | 3.4998 mL |
| 10 mM | 0.1750 mL | 0.8750 mL | 1.7499 mL |
| 50 mM | 0.0350 mL | 0.1750 mL | 0.3500 mL |
Description
AZ3451 is a potent antagonist of that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.
Targets
| PAR2 [1] (Cell-free assay) |
| 23 nM |
In vitro
AZ3451 is a PAR2 antagonist that plays a part in inflammation response, apoptosis, autophagy and cellular senescence during Osteoarthritis (OA). AZ3451 prevents the IL-1β-induced inflammation response, cartilage degradation and premature senescence in chondrocytes. AZ3451 attenuates chondrocytes apoptosis by activating autophagy in vitro. The P38/MAPK, NF-κB and PI3K/AKT/mTOR pathways are involved in the protective effect of AZ3451.
References
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