[CAS NO. 1801344-14-8] Emavusertib (CA-4948)
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PRODUCTS SPECIFICATIONS [1801344-14-8]
Store
Catalog
SLK-S9779
Brand
Selleck
CAS
1801344-14-8
DESCRIPTION [1801344-14-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 491.50 |
| Molecular Formula | C24H25N7O5 |
| SMILES | N(C(=O)C=1N=C(OC1)C=2C=C(C)N=CC2)C3=C(N=C4C(=C3)OC(=N4)N5CCOCC5)N6CC[C@@H](O)C6 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0346 mL | 10.1729 mL | 20.3459 mL |
| 5 mM | 0.4069 mL | 2.0346 mL | 4.0692 mL |
| 10 mM | 0.2035 mL | 1.0173 mL | 2.0346 mL |
| 50 mM | 0.0407 mL | 0.2035 mL | 0.4069 mL |
Description
Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of with anti-tumor activity.
In vitro
Emavusertib (CA-4948) is over 500-fold more selective for IRAK-4 compared to IRAK-1. Emavusertib (CA-4948) reduces TNF-α, IL-1β, IL-6 and IL-8 release from TLR-Stimulated THP-1 Cells with an IC50 <250 nM. Emavusertib (CA-4948) has antiproliferative activity due to inhibition of receptor-type tyrosine-protein kinase FLT3.
References
Synonyms
4-Oxazolecarboxamide, N-[5-[(3R)-3-hydroxy-1-pyrrolidinyl]-2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl]-2-(2-methyl-4-pyridinyl)-
N-[5-[(3R)-3-Hydroxy-1-pyrrolidinyl]-2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide
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