[CAS NO. 2101700-15-4] Pirtobrutinib (LOXO-305)
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [2101700-15-4]
Store
Catalog
SLK-S9825
Brand
Selleck
CAS
2101700-15-4
DESCRIPTION [2101700-15-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 479.43 |
| Molecular Formula | C22H21F4N5O3 |
| SMILES | C(N)(=O)C=1C(=NN([C@H](C(F)(F)F)C)C1N)C2=CC=C(CNC(=O)C3=C(OC)C=CC(F)=C3)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0858 mL | 10.4291 mL | 20.8581 mL |
| 5 mM | 0.4172 mL | 2.0858 mL | 4.1716 mL |
| 10 mM | 0.2086 mL | 1.0429 mL | 2.0858 mL |
| 50 mM | 0.0417 mL | 0.2086 mL | 0.4172 mL |
Targets
| BTK [1] (in WT BTK HEK cells) |
| 5.69 nM |
In vitro
Pirtobrutinib (LOXO-305) is a highly selective, non-covalent, next-generation Bruton's tyrosine kinase (BTK) inhibitor, which potently inhibits the cellular activity of BTK C481S, T and R mutations and displays strong equilibrium binding to WT BTK and several BTK C481 substitution mutations.[2]
References
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.