[CAS NO. 39674-97-0] BVT-948
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [39674-97-0]
Store
Catalog
SLK-S9829
Brand
Selleck
CAS
39674-97-0
DESCRIPTION [39674-97-0]
Overview
| MDL | MFCD00616487 |
|---|---|
| Molecular Weight | 241.24 |
| Molecular Formula | C14H11NO3 |
| SMILES | O=C(C(C)(C)C1=C2O)N=C1C3=CC=CC=C3C2=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1452 mL | 20.7262 mL | 41.4525 mL |
| 5 mM | 0.8290 mL | 4.1452 mL | 8.2905 mL |
| 10 mM | 0.4145 mL | 2.0726 mL | 4.1452 mL |
| 50 mM | 0.0829 mL | 0.4145 mL | 0.8290 mL |
Description
BVT 948 is a irreversible, noncompetitive and cell-permeable inhibitor with IC50s of 0.9 μM, 1.7 μM, 0.09 μM, 1.5 μM and 0.7 μM for PTP1B, TCPTP, SHP-2, LAR and YopH respectively.
Targets
In vitro
In L6 myotubes, PTP1B is oxidized further to the irreversible sulfinic and sulfonic forms with BVT.948. BVT.948 is able to increase tyrosine phosphorylation of cellular proteins, including the insulin receptor. BVT.948 inhibits several other PTPs tested and also was efficient at inhibiting several cytochrome P450 (P450) isoforms.
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.