[CAS NO. 371924-24-2] MCU-i4
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PRODUCTS SPECIFICATIONS [371924-24-2]
Store
Catalog
SLK-S9842
Brand
Selleck
CAS
371924-24-2
DESCRIPTION [371924-24-2]
Overview
| MDL | MFCD02730422 |
|---|---|
| Molecular Weight | 377.48 |
| Molecular Formula | C23H27N3O2 |
| SMILES | O=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6491 mL | 13.2457 mL | 26.4915 mL |
| 5 mM | 0.5298 mL | 2.6491 mL | 5.2983 mL |
| 10 mM | 0.2649 mL | 1.3246 mL | 2.6491 mL |
| 50 mM | 0.0530 mL | 0.2649 mL | 0.5298 mL |
Description
MCU-i4 is a negative modulator of the complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.
Targets
| MCU1 [1] |
In vitro
MCU-i4 decreases mitochondrial Ca2+ influx. Docking simulations reveal that MCU-i4 directly binds a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of MCU-i4 is lost. Moreover, MCU-i4 fails to inhibit mitochondrial Ca2+ uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft.
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