[CAS NO. 1398046-21-3] Proxalutamide (GT0918)

Name: Proxalutamide (GT0918)
Brand: Arctom Scientific
SKU: SLK-S9898

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PRODUCTS SPECIFICATIONS [1398046-21-3]

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Catalog

SLK-S9898

Brand

Selleck

CAS

1398046-21-3

DESCRIPTION [1398046-21-3]

Overview

MDL	MFCD28502231
Molecular Weight	517.50
Molecular Formula	C24H19F4N5O2S
SMILES	S=C1N(C(=O)C(C)(C)N1C=2C=CC(CCCC3=NC=CO3)=NC2)C4=C(F)C(C(F)(F)F)=C(C#N)C=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9324 mL	9.6618 mL	19.3237 mL
5 mM	0.3865 mL	1.9324 mL	3.8647 mL
10 mM	0.1932 mL	0.9662 mL	1.9324 mL
50 mM	0.0386 mL	0.1932 mL	0.3865 mL

Targets

Androgen Receptor ^[1]
(in the AR competive binding assay)

32 nM

In vitro

Proxalutamide, a novel 2nd generation AR antagonist, binds to the ligand- binding domain of AR, with an IC50 of 32 nM in the AR competitive binding assays. Proxalutamide can block AR transcriptional activity, reduce AR protein levels, and obviously inhibit PCa growth in vitro. ^[1]

References

[1] Tie Zhou, et, al. Eur J Cancer. 2020 Jul;134:29-40.
[2] Sang H, et al. Rapid Commun Mass Spectrom. 2021 Feb 15;35(3):e9003.

Synonyms

Benzonitrile, 4-[4,4-dimethyl-3-[6-[3-(2-oxazolyl)propyl]-3-pyridinyl]-5-oxo-2-thioxo-1-imidazolidinyl]-3-fluoro-2-(trifluoromethyl)-

4-[4,4-Dimethyl-3-[6-[3-(2-oxazolyl)propyl]-3-pyridinyl]-5-oxo-2-thioxo-1-imidazolidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile

GT 0918

Proxalutamide