[CAS NO. 2110428-64-1] JNJ-63576253 (TRC-253)
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PRODUCTS SPECIFICATIONS [2110428-64-1]
Store
Catalog
SLK-S9900
Brand
Selleck
CAS
2110428-64-1
DESCRIPTION [2110428-64-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 538.97 |
| Molecular Formula | C23H22ClF3N6O2S |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8554 mL | 9.2770 mL | 18.5539 mL |
| 5 mM | 0.3711 mL | 1.8554 mL | 3.7108 mL |
| 10 mM | 0.1855 mL | 0.9277 mL | 1.8554 mL |
| 50 mM | 0.0371 mL | 0.1855 mL | 0.3711 mL |
Description
JNJ-63576253 (TRC-253) is a potent and selective Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.
Targets
| Androgen receptor [1] (Cell-free assay) |
| 6.9 nM |
In vitro
JNJ-63576253 can inhibit transcriptional activity in reporter assays, cellular proliferation, and AR downstream target gene expression, as a potent and selective next-generation AR pathway inhibitor. [1]
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