[CAS NO. 314291-83-3] PHPS1

Name: PHPS1
Brand: Arctom Scientific
SKU: SLK-S9913

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PRODUCTS SPECIFICATIONS [314291-83-3]

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Catalog

SLK-S9913

Brand

Selleck

CAS

314291-83-3

DESCRIPTION [314291-83-3]

Overview

MDL	-
Molecular Weight	465.44
Molecular Formula	C21H15N5O6S
SMILES	O=S(C1=CC=C(NN=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=CC=C4)C2=O)C=C1)(O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1485 mL	10.7425 mL	21.4850 mL
5 mM	0.4297 mL	2.1485 mL	4.2970 mL
10 mM	0.2149 mL	1.0743 mL	2.1485 mL
50 mM	0.0430 mL	0.2149 mL	0.4297 mL

Targets

Shp2 ^[1]
(Cell-free assay)

0.73 μM(Ki)

In vitro

PHPS1 inhibits Shp2-dependent cellular events such as hepatocyte growth factor/scatter factor (HGF/SF)-induced epithelial cell scattering and branching morphogenesis. PHPS1 also blocks Shp2-dependent downstream signaling, namely HGF/SF-induced sustained phosphorylation of the Erk1/2 MAP kinases and dephosphorylation of paxillin. Furthermore, PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.

References

[1] Klaus Hellmuth , et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80.
[2] Jia Chen, et al. BMC Cardiovasc Disord. 2018 Apr 27;18(1):72.