[CAS NO. 338404-52-7] CITCO
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PRODUCTS SPECIFICATIONS [338404-52-7]
Store
Catalog
SLK-S9914
Brand
Selleck
CAS
338404-52-7
DESCRIPTION [338404-52-7]
Overview
| MDL | MFCD00139608 |
|---|---|
| Molecular Weight | 436.74 |
| Molecular Formula | C19H12Cl3N3OS |
| SMILES | C(=NOCC1=CC(Cl)=C(Cl)C=C1)C2=C(N=C3N2C=CS3)C4=CC=C(Cl)C=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2897 mL | 11.4485 mL | 22.8969 mL |
| 5 mM | 0.4579 mL | 2.2897 mL | 4.5794 mL |
| 10 mM | 0.2290 mL | 1.1448 mL | 2.2897 mL |
| 50 mM | 0.0458 mL | 0.2290 mL | 0.4579 mL |
Targets
| CAR [1] (in CAR/SRC-1 FRET assay) |
| 49 nM(EC50) |
In vitro
CITCO (1-50 μM; 48 hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs. CITCO (2.5, 5 μM; 48 hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes. CITCO (2.5-10 μM; 48 hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes. CITCO (0-25 μM; 48 hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein.[2]
References
Synonyms
Imidazo[2,1-b]thiazole-5-carboxaldehyde, 6-(4-chlorophenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime
6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carboxaldehyde O-[(3,4-dichlorophenyl)methyl]oxime
CITCO
6-(4-Chlorophenyl)imidazo-[2,1-b]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
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