[CAS NO. ]  4-ArmPEG-NH2

• Synonyms：
  4-ArmPEG-Amine
  
• Purity：
  ≥95%
• Recommended Storage Condition：
  Store at -5°C,keep in dry and avoid sunlight.
• Uses：
  Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

4 Arm PEG Amine (4-ArmPEG-NH2) is a multi-arm PEG derivative with amine groups at each terminal of the four arms connected to one pentaerythritol core that can be used to prepare hydrogel or modify proteins, peptides and other materials via their functional groups. PEG hydrogels have a variety of applications in medical devices and regenerative medicine, and are especially of interest for controlled release of drugs, for 2D and 3D cell culture, and for wound sealing and healing.​

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Cited Publications

This PEG derivative has been cited in peer-reviewed scientific publications. Browse the references below to learn more.

1. Kawabata, K., Hoshino, T., & Takeoka, Y. (2025).Development of a Temperature-Responsive Polymer Network with Enhanced Transparency and Volume Shrinkage via Star-Shaped PEG-b-PNIPA Block Copolymer. Materials and Interfaces, 2(3), 285–301. https://doi.org/10.53941/mi.2025.100022
2. Yeingst, T.J.; Helton, A.M.; Rawnaque, F.S.; Arrizabalaga, J.H.; Ravnic, D.J.; Simon, J.C.; Hayes, D.J. Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration. Gels 2025, 11, 120. https://doi.org/10.3390/gels11020120 
3. Thermo-responsive injectable hydrogels from linear and star-shaped block copolymers composed of amino acid-derived vinyl polymer and poly(ethylene glycol) for biomedical applications, Mater. Adv., 2024,5, 665-674, https://doi.org/10.1039/D3MA00954H 
4. All-Covalent Nuclease-Resistant and Hydrogel-Tethered DNA Hairpin Probes Map pN Cell Traction Forces, Sk Aysha Rashid, Yixiao Dong, Hiroaki Ogasawara, Maia Vierengel, Mark Edoho Essien, and Khalid Salaita, ACS Applied Materials & Interfaces 2023 15 (28), 33362-33372, DOI: 10.1021/acsami.3c04826 
5. Shirasu, T., Yodsanit, N., Xie, X., Zhao, Y., Wang, Y., Xie, R., Huang, Y., Wang, B., Urabe, G., Gong, S., Guo, L., & Kent, K. C. (2021). An adventitial painting modality of local drug delivery to abate intimal hyperplasia. Biomaterials, 275, 120968. https://doi.org/10.1016/j.biomaterials.2021.120968 
6. Nicolella, P., Lauxen, D., Ahmadi, M., & Seiffert, S. (2021). Reversible Hydrogels with Switchable Diffusive Permeability. Macromolecular Chemistry and Physics, 222(16), 2100076. https://doi.org/10.1002/macp.202100076

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