SH-PEG-Silane, also known as thiol-PEG-silane, is a PEG chain terminated with a thiol group (SH) and a silane group. The thiol group enables selective conjugation to surfaces or molecules containing suitable functional groups, such as maleimides or acrylates, through thiol-ene or thiol-maleimide chemistry, respectively. The silane group facilitates covalent attachment to various surfaces, including glass, silicon, and metal oxide surfaces, through silanization reactions, forming stable bonds with the substrate. SH-PEG-Silane is commonly employed in the development of functionalized surfaces, biosensors, drug delivery systems, and biomaterials due to its versatility, biocompatibility, and ability to introduce specific functionalities to surfaces or molecules.
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