[CAS NO. 1392499-32-9] Br-PEG4-NH-Boc
PRODUCTS SPECIFICATIONS [1392499-32-9]
DESCRIPTION [1392499-32-9]
- CAS No.：
1392499-32-9 - Synonyms：
N-Boc-PEG4-bromide - Purity：
≥95% - MF：
C15H30BrNO6 - MW：
400.31 - Recommended Storage Condition：
Store at -5°C,keep in dry and avoid sunlight. - Uses：
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
Br-PEG4-NH-Boc is a versatile PEG linker featuring a bromide group and a Boc-protected amino group. The hydrophilic PEG spacer enhances solubility in aqueous media, while the bromide serves as an excellent leaving group for nucleophilic substitution reactions. The Boc group can be easily removed under mild acidic conditions, yielding a free amine for further functionalization.
Biological Applications
Br-PEG4-NH-Boc functions as a PROTAC linker within the PEG and alkyl/ether classes, enabling the synthesis of diverse PROTAC molecules. Additionally, it serves as a cleavable ADC linker, playing a crucial role in the development of antibody-drug conjugates (ADCs) for targeted therapeutic applications.
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