[CAS NO. 114311-32-9] Imazamox
PRODUCTS SPECIFICATIONS [114311-32-9]
DESCRIPTION [114311-32-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 305.33 |
| Molecular Formula | C15H19N3O4 |
| SMILES | O=C(C1=CC(COC)=CN=C1C(NC2(C)C(C)C)=NC2=O)O |
Summary
Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death [1] [2] .
In Vitro
Half-life of Imazamox in the soil ranges from 1 to 3 months exhibit low mammalian toxicity [1] . Plants are treated with Imazamox (250 μM) in the nutrient solution and harvested 7 days after. Imazamox is mainly accumulated in V. sativa , six fold higher than those detected in P.vulgaris [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Imazamox (12-36 mg/kg; intraperitoneal injection; for 24-72 hours; male Sprague-Dawley rats) treatment induces toxic effects in the liver and pancreas of Sprague Dawley rats. Necrotic and degenerative changes are detected in hepatocytes at the two highest doses. Imazamox treatment reduces the size of the β-islet cells, and also induces an elevation in serum glucose and calcium [4] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 50 male Sprague-Dawley rats (300 ± 10 g) [3] |
| Dosage: | 12 mg/kg, 24 mg/kg and 36 mg/kg |
| Administration: | Intraperitoneal injection; for 24 hours, 48 hours or 72 hours |
| Result: | Induced toxic effects in the liver and pancreas. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 20 mg/mL ( 65.50 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2751 mL | 16.3757 mL | 32.7515 mL |
| 5 mM | 0.6550 mL | 3.2751 mL | 6.5503 mL |
| 10 mM | 0.3275 mL | 1.6376 mL | 3.2751 mL |
References
- [1] Wei J et al. Enantioselective Phytotoxicity of Imazamox Against Maize Seedlings. Bull Environ Contam Toxicol. 2016 Feb;96(2):242-7.
- [2] García-Garijo A, et al. Metabolic responses in root nodules of Phaseolus vulgaris and Vicia sativa exposed to the imazamox herbicide. Pestic Biochem Physiol. 2014 May;111:19-23.
- [3] Imazamox Chemical Fact Sheet. Wisconsin Department of Natural Resources. DNR PUB-WT-974 2012.
- [4] Sevim Ç, et al. An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas. Toxicol Rep. 2018 Nov 19;6:42-50.
Synonyms
