[CAS NO. 122453-73-0] Chlorfenapyr
PRODUCTS SPECIFICATIONS [122453-73-0]
DESCRIPTION [122453-73-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 407.61 |
| Molecular Formula | C15H11BrClF3N2O |
| SMILES | N#CC1=C(C2=CC=C(Cl)C=C2)N(COCC)C(C(F)(F)F)=C1Br |
Summary
Chlorfenapyr is a pyrrole insecticide. Chlorfenapyr has a mode of action: the mixed function oxidase oxidizes and removes the Nethoxymethyl group to form the active metabolite, CL 303268. Chlorfenapyr is used for termite control and crop protection against a variety of insect and mite pests [1] [2] .
In Vitro
Chlorfenapyr is a pro-insecticide and oxidative removal of the N-ethoxymethyl group of Chlorfenapyr by mixed function oxidases leads to a toxic form identified as CL 303268 which functions to uncouple oxidative phosphorylation in the mitochondria, resulting in disruption of ATP production and loss of energy leading to cell dysfunction and subsequent death of the organism. This molecule has low mammalian toxicity [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04230161 | PATH|Rwanda Biomedical Centre|University of Rwanda|Liverpool School of Tropical Medicine |
Malaria
|
February 24, 2020 | |
| NCT04157894 | PATH|Centre national de recherche et de formation sur le paludisme|Liverpool School of Tropical Medicine |
Malaria
|
July 7, 2019 | |
| NCT04716387 | PATH|Tropical Health LLP|Ministry of Health, Mozambique|Instituto Nacional de Saúde|Tulane University|Liverpool School of Tropical Medicine |
Malaria
|
August 18, 2020 | |
| NCT03554616 | London School of Hygiene and Tropical Medicine|Kilimanjaro Christian Medical Centre, Tanzania|National Institute for Medical Research, Tanzania|University of Ottawa |
Malaria|Anaemia
|
February 1, 2019 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 613.33 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4533 mL | 12.2666 mL | 24.5333 mL |
| 5 mM | 0.4907 mL | 2.4533 mL | 4.9067 mL |
| 10 mM | 0.2453 mL | 1.2267 mL | 2.4533 mL |
References
- [1] Byung Hyun Baek, et al. Chlorfenapyr-Induced Toxic Leukoencephalopathy with Radiologic Reversibility: A Case Report and Literature Review. Korean J Radiol. 2016 Mar-Apr;17(2):277-80.
- [2] Kamaraju Raghavendra, et al. Chlorfenapyr: a new insecticide with novel mode of action can control pyrethroid resistant malaria vectors. Malar J. 2011 Jan 25;10:16.
Synonyms
