Cysteine Protease Focused Library

Format & Volume

10 μL/well Solution

30 μL/well Solution

50 μL/well Solution

100 μL/well Solution

Compounds

9,000

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ATTRIBUTES

Store

Catalog

HY-L925

Brand

MCE

OVERVIEW

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors.

This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Description & Advantages

Name: Cysteine Protease Focused Library
Brand: Arctom Scientific
SKU: HY-L925

• A unique collection of 9,000 compounds can be used for efficient discovery of novel cysteine protease inhibitors.

• All compounds are screened via AI models to get a collection retaining the critical pharmacological and shape features of reported CP inhibitors.

• All compounds are available off the shelf.

• All compounds are validated by LC-MS or NMR to ensure high purity and quality.

Product Details

Formulation:

The 9,000 compounds obtained via AI-driven screening serve as a valuable tool for discovering novel cysteine protease inhibitors.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

Publications Citing Use of MedChemExpress (MCE) Products