[CAS NO. 528-43-8] Magnolol

Name: Magnolol
Brand: Arctom Scientific
SKU: HY-N0163

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PRODUCTS SPECIFICATIONS [528-43-8]

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Catalog

HY-N0163

Brand

MCE

CAS

528-43-8

DESCRIPTION [528-43-8]

Overview

MDL	MFCD00016658
Molecular Weight	266.33
Molecular Formula	C18H18O2
SMILES	OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]J Nat Med. 2021 Oct 27.

Summary

Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis , is a dual agonist of both RXRα and PPARγ , with EC ₅₀ values of 10.4 µM and 17.7 µM, respectively.

IC50 & Target

PPARγ

17.7 μM (EC ₅₀ )

In Vitro

Magnolol is a dual agonist of both RXRα and PPARγ, with EC ₅₀ values of 10.4 µM and 17.7 µM, respectively. Magnolol (26.2-80 µM) binds to RXRαLBD and PPARγLBD in a dose dependent manner, with K _d values of 45.7 µM and 1.67 µM, respectively. Magnolol (1-20 µM) induces the transcription of PPRE in a dose-dependent manner, but shows no activity on RXRE transcription ^[1] . Magnolol (1, 3, 10 µM) enhances adipocyte differentiation of both 3T3-L1 pre-adipocystes and C3H10T1/2 pluripotent stem cells in the presence of insulin. Magnolol (10 μM) upregulates mRNA expression of marker genes for adipocyte differentiation. Magnolol (1, 10 μM) shows an increase in basal and insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 375.47 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7547 mL	18.7737 mL	37.5474 mL
5 mM	0.7509 mL	3.7547 mL	7.5095 mL
10 mM	0.3755 mL	1.8774 mL	3.7547 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

[1,1′-Biphenyl]-2,2′-diol, 5,5′-di-2-propen-1-yl-

2,2′-Bichavicol

2,2′-Biphenyldiol, 5,5′-diallyl-

[1,1′-Biphenyl]-2,2′-diol, 5,5′-di-2-propenyl-

5,5′-Di-2-propen-1-yl[1,1′-biphenyl]-2,2′-diol

Magnolol

5,5′-Diallyl-2,2′-biphenyldiol

NSC 293099

2-(2-Hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol