[CAS NO. 19685-10-0] 10-Methoxycamptothecin

Name: 10-Methoxycamptothecin
Brand: Arctom Scientific
SKU: HY-N0446

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PRODUCTS SPECIFICATIONS [19685-10-0]

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Catalog

HY-N0446

Brand

MCE

CAS

19685-10-0

DESCRIPTION [19685-10-0]

Overview

MDL	-
Molecular Weight	378.38
Molecular Formula	C21H18N2O5
SMILES	O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(OC)=CC=C5N=C4C3=C2)=O

For research use only. We do not sell to patients.

Summary

10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata , and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL ( 22.01 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6428 mL	13.2142 mL	26.4285 mL
5 mM	0.5286 mL	2.6428 mL	5.2857 mL
10 mM	0.2643 mL	1.3214 mL	2.6428 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 0.83 mg/mL (2.19 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.83 mg/mL (2.19 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (2.19 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zheng J, et al. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 201