[CAS NO. 24316-19-6] Cephalotaxine

Name: Cephalotaxine
Brand: Arctom Scientific
SKU: HY-N0838

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PRODUCTS SPECIFICATIONS [24316-19-6]

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Catalog

HY-N0838

Brand

MCE

CAS

24316-19-6

DESCRIPTION [24316-19-6]

Overview

MDL	MFCD00063372
Molecular Weight	315.36
Molecular Formula	C18H21NO4
SMILES	O[C@H]1[C@](C(C=C(OCO2)C2=C3)=C3CCN4CCC5)([H])[C@]45C=C1OC

For research use only. We do not sell to patients.

Summary

Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei , with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity ^[1] ^[2] ^[3] .

IC50 & Target

ZIKV ^[3]

In Vitro

Cephalotaxine inhibits Zika infection by impeding viral replication and stability ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 79.27 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1710 mL	15.8549 mL	31.7098 mL
5 mM	0.6342 mL	3.1710 mL	6.3420 mL
10 mM	0.3171 mL	1.5855 mL	3.1710 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Cephalotaxine

4H-Cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol, 1,5,6,8,9,14b-hexahydro-2-methoxy-, [1S-(1α,3aS*,14bβ)]-

[1S-(1α,3aS*,14bβ)]-1,5,6,8,9,14b-Hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol

(-)-Cephalotaxine

NSC 128487

NSC 245454

ZINC 19795976