[CAS NO. 610-88-8] Tenuazonic acid

Name: Tenuazonic acid
Brand: Arctom Scientific
SKU: HY-N6715

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PRODUCTS SPECIFICATIONS [610-88-8]

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Catalog

HY-N6715

Brand

MCE

CAS

610-88-8

DESCRIPTION [610-88-8]

Overview

MDL	-
Molecular Weight	197.23
Molecular Formula	C10H15NO3
SMILES	O=C1N[C@@H]([C@@H](C)CC)C(O)=C1C(C)=O

For research use only. We do not sell to patients.

Summary

Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products , is a putative nonhost-selective mycotoxin isolated from Alternaria alternate ^[1] . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor ^[2] .

IC50 & Target

PSII ^[2]

Appearance

Solid

Source

Alternaria alternata

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 253.51 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0702 mL	25.3511 mL	50.7022 mL
5 mM	1.0140 mL	5.0702 mL	10.1404 mL
10 mM	0.5070 mL	2.5351 mL	5.0702 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.25 mg/mL (6.34 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (6.34 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (6.34 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2H-Pyrrol-2-one, 3-acetyl-1,5-dihydro-4-hydroxy-5-[(1S)-1-methylpropyl]-, (5S)-

3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

2H-Pyrrol-2-one, 3-acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-, [S-(R*,R*)]-

Tenuazonic acid

(5S)-3-Acetyl-1,5-dihydro-4-hydroxy-5-[(1S)-1-methylpropyl]-2H-pyrrol-2-one

L-Tenuazonic acid

AAC-toxin