[CAS NO. 519-02-8] (+)-Matrine

Name: (+)-Matrine
Brand: Arctom Scientific
SKU: SLK-S2322

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PRODUCTS SPECIFICATIONS [519-02-8]

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Catalog

SLK-S2322

Brand

Selleck

CAS

519-02-8

DESCRIPTION [519-02-8]

Overview

MDL	-
Molecular Weight	248.36
Molecular Formula	C15H24N2O
SMILES	O=C1N2[C@@]([C@@]3([C@@]4([C@](C2)(CCCN4CCC3)[H])[H])[H])(CCC1)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.0264 mL	20.1321 mL	40.2641 mL
5 mM	0.8053 mL	4.0264 mL	8.0528 mL
10 mM	0.4026 mL	2.0132 mL	4.0264 mL
50 mM	0.0805 mL	0.4026 mL	0.8053 mL

Description

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.

Targets

κ-opioid receptor ^[1]

In vitro

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice.

In vivo

LD50: Mice 157mg/kg (i.p.)

References

[1] Zhang Y, et al. Cytotechnology, 2009, 59(3), 191-200.
[2] Higashiyama K, et al. Biol Pharm Bull, 2005, 28(5), 845-848.
[3] Wang XY, et al. Nanfang Yike Daxue Xuebao, 2010, 30(9), 2154-2155.

Synonyms

1H,5H,10H-Dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aS,13aR,13bR,13cS)-

Matrine

Matridin-15-one

(7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one

(+)-Matrine

α-Matrine

NSC 146051

NSC 318810

Vegard

Bioca

Matrine-fluensulfone mixt.