[CAS NO. 10338-51-9] Salidroside

Name: Salidroside
Brand: Arctom Scientific
SKU: SLK-S2396

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PRODUCTS SPECIFICATIONS [10338-51-9]

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Catalog

SLK-S2396

Brand

Selleck

CAS

10338-51-9

DESCRIPTION [10338-51-9]

Overview

MDL	MFCD00210553
Molecular Weight	300.3
Molecular Formula	C14H20O7
SMILES	O(CCC1=CC=C(O)C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3300 mL	16.6500 mL	33.3000 mL
5 mM	0.6660 mL	3.3300 mL	6.6600 mL
10 mM	0.3330 mL	1.6650 mL	3.3300 mL
50 mM	0.0666 mL	0.3330 mL	0.6660 mL

Description

Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

In vitro

Salidroside inhibits the growth of various human cancer cell lines in concentration- and time-dependent manners, and the sensitivity to salidroside is different in those cancer cell lines. Salidroside could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, salidroside resultes in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulates the levels of p27(Kip1) and p21(Cip1). Salidroside also alleviates cell viability loss and apoptotic cell death induced by H(2)O(2) stimulation in cultured NGF-differentiated PC12 cells by activating ERK1/2 pathway and inhibiting caspase-3 activation. Salidroside activates the PI3K/Akt pathway resulting in protective effects against MPP(+)-induced apoptosis in PC12 cells, which may be used in the treatment of Parkinson's disease (PD).

In vivo

Salidroside (20, 50 and 100 mg/kg) protects liver tissue from the oxidative stress elicited by D-galactosamine and lipopolysaccharide.

References

[1] Hu X, et al. Cell Biol Toxicol, 2010, 26(6), 499-507.
[2] Yu S, et al. J Mol Neurosci, 2010, 40(3), 321-331.
[3] Zhang L, et al. Food Chem Toxicol, 2012, 50(8), 2591-2597.
[4] Wu YL, et al. J Pharm Pharmacol, 2009, 61(10), 1375-1382.

Synonyms

β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl

Salidroside

Glucopyranoside, p-hydroxyphenethyl

2-(4-Hydroxyphenyl)ethyl β-D-glucopyranoside

Rhodioloside

Rhodosin

Tyrosol α-(β-D-glucopyranoside)

4-Hydroxyphenyl-2-ethyl-β-D-glucopyranoside

Sallidroside

(2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-[2-(4-hydroxyphenyl)ethoxy] oxane-3,4,5-triol