[CAS NO. 20830-75-5] Digoxin (NSC 95100)

Name: Digoxin (NSC 95100)
Brand: Arctom Scientific
SKU: SLK-S4290

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PRODUCTS SPECIFICATIONS [20830-75-5]

Store

Catalog

SLK-S4290

Brand

Selleck

CAS

20830-75-5

DESCRIPTION [20830-75-5]

Overview

MDL	-
Molecular Weight	780.94
Molecular Formula	C41H64O14
SMILES	O[C@@]12[C@@](C)([C@](CC1)(C3=CC(=O)OC3)[H])[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.2805 mL	6.4025 mL	12.8051 mL
5 mM	0.2561 mL	1.2805 mL	2.5610 mL
10 mM	0.1281 mL	0.6403 mL	1.2805 mL
50 mM	0.0256 mL	0.1281 mL	0.2561 mL

Description

Digoxin (NSC 95100) is a classical inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.

Targets

Na,K-ATPase α2β3 ^[1]	Na,K-ATPase α2β1 ^[1]	Na,K-ATPase α1β1 ^[1]
42.8 nM(Ki)	58.7 nM(Ki)	268 nM(Ki)

References

[1] Katz A, et al. Proc Natl Acad Sci U S A. 2015, 112(44):13723-8.

Synonyms

Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-

Digoxin

Digitoxin, 12β-hydroxy-

(3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide

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Digoxin Nativelle

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Digicor

Digomal

Digon

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Cardioxin

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Lanorale

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Purgoxin

Toloxin

Eudigox

Fargoxin

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Dokim

Stillacor

Vanoxin

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NSC 95100

Cardixin

Digitek