[CAS NO. 504-24-5] 4-Aminopyridine

Name: 4-Aminopyridine
Brand: Arctom Scientific
SKU: SLK-S5028

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PRODUCTS SPECIFICATIONS [504-24-5]

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Catalog

SLK-S5028

Brand

Selleck

CAS

504-24-5

DESCRIPTION [504-24-5]

Overview

MDL	-
Molecular Weight	94.11
Molecular Formula	C5H6N2
SMILES	NC=1C=CN=CC1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	10.6259 mL	53.1293 mL	106.2586 mL
5 mM	2.1252 mL	10.6259 mL	21.2517 mL
10 mM	1.0626 mL	5.3129 mL	10.6259 mL
50 mM	0.2125 mL	1.0626 mL	2.1252 mL

Description

4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.

Targets

In vitro

Working from the intracellular side of the channel, 4-AP inhibits a wide variety of voltage-dependent K+ channels with affinities ranging from the mid-micromolar to the millimolar range.

References

[1] Smith C, et al. Clin Exp Pharmacol Physiol. 2009, 36(11):1104-9
[2] Gutman GA, et al. Pharmacol Rev. 2005, 57(4):473-508.

Synonyms

4-Pyridinamine

Pyridine, 4-amino-

4-Aminopyridine

VMI 10-3

Phillips 1861

γ-Aminopyridine

p-Aminopyridine

4-Pyridylamine

Avitrol

EL 970

Fampridine

4-Pyridinylamine

4AP

NSC 15041

Neurelan

Ampyra

Dalfampridine

Pymadin

Fampyra