[CAS NO. 50-07-7] Mitomycin C

Name: Mitomycin C
Brand: Arctom Scientific
SKU: SLK-S8146

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [50-07-7]

Store

Catalog

SLK-S8146

Brand

Selleck

CAS

50-07-7

DESCRIPTION [50-07-7]

Overview

MDL	-
Molecular Weight	334.37
Molecular Formula	C15H18N4O5
SMILES	O(C)[C@]12N(C3=C([C@H]1COC(N)=O)C(=O)C(N)=C(C)C3=O)C[C@]4([C@@]2(N4)[H])[H]

For research use only.

Storage

3 years -20°C(in the dark) powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces in a caspases-dependent and Fas/CD95-independent manner.

Targets

DNA synthesis ^[1]

In vitro

Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity.

References

[1] Ben-Yehoyada M, et al. Mol Cell. 2009, 35(5), 704-715.
[2] Cheng H, et al. Cell Cycle. 2012, 11(17), 3312-3323.
[3] Sharma V, et al. Indian J Biochem Biophys. 2014, 51(1), 46-51.
[4] Jankun J, et al. Int J Oncol. 2014, 44(1), 147-152.

Synonyms

Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-

Mitomycin C

Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)

Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-

(1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione

Ametycine

NSC 26980

Mitomycin

MitoExtra

Mitonco

Mitoplus

MMC

Mitocin C

Mutamycin

Mytomycin Kyowa S

Mitozytrex