[CAS NO. 1609392-27-9] Deucravacitinib (BMS-986165)
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PRODUCTS SPECIFICATIONS [1609392-27-9]
Store
Catalog
SLK-S8879
Brand
Selleck
CAS
1609392-27-9
DESCRIPTION [1609392-27-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 425.46 |
| Molecular Formula | C20H19D3N8O3 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3504 mL | 11.7520 mL | 23.5040 mL |
| 5 mM | 0.4701 mL | 2.3504 mL | 4.7008 mL |
| 10 mM | 0.2350 mL | 1.1752 mL | 2.3504 mL |
| 50 mM | 0.0470 mL | 0.2350 mL | 0.4701 mL |
Description
Deucravacitinib (BMS-986165) is a highly potent and selective allosteric inhibitor of with a Ki value of 0.02 nM for binding to the Tyk2 pseudokinase domain. It is highly selective against a panel of 265 kinases and pseudokinases.
Targets
| Tyk2 [1] (Cell-free assay) |
| 0.02 nM |
In vitro
BMS-986165 is highly differentiated from all other reported JAK/TYK2 inhibitors due to its ability to achieve an unprecedented level of selectivity for TYK2, especially over JAK1, JAK2, and JAK3.
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